First Download and Install Last.FM scrobbler, then you will have to install ZuseMe. While Installing Zuse, choose the folder where you have Zune installed to
Installation Instructions
1. Install the latest Zune Desktop Software.
2. Install the Last.fm client and login (Allow scrobbling from all harddrives)
3. Make sure that you installed the requirements (.NET Framework 4 / Visual C++)
4. Extract the ZuseMe directory to any directory you want.
5. Launch ZuseMe.exe (Runs hidden in the background/tray menu)