Having used and administered Xerox DocuMate scanners and OneTouch software (though not this specific model, and not with Windows 10), I can say that the order in which you install the scanner drivers and the OneTouch software is important. I imagine your upgrade to Windows 10 may have "refreshed" the drivers, thus putting things out of order and causing the whole thing to not work anymore.
I found that typically, when things go wrong with the software, the most effective course is to:
- Uninstall OneTouch, uninstall the Xerox DocuMate drivers, and uninstall PaperPort (if you're using it).
- Reboot your computer.
- If you have the installation CD, use that to walk you through reinstalling the drivers and software. If you do not have the original CD, then you'll want to install things in this order: Drivers, then OneTouch, then PaperPort (if you're using it).