Am I correct in reading that command-option-P-R no longer fixes the issue or the sequence itself no longer restarts the computer?
The distinction is important as you may have a hardware issue. If it is a hardware issue the extent depends on what year Retina and what size it is. Some models have the trackpad, keyboard and power button going directly to the logic board while some have the keyboard loop through the trackpad (if I remember correctly, it's basically opposite of how the MacBook Air would be internally).
Hopefully it's just the sequence not fixing the issue because then it sounds like a software issue (possible reinstall of the operating system).
One way to test is to power on and hold the option key. It should show a row of icons showing what you can boot from. If you don't see one listed as Recovery then restart one more time and hold command-R. This will boot you to the recovery disk, see if the pointer and keyboard work there. If they do then a reinstall is looking to be the likely solution.